

| 货号 | HP941014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 品牌 | abinScience | ||||||||
| 种属反应性 | Human, Mouse, Rat | ||||||||
| 应用 | ELISA, IHC, WB | ||||||||
| 宿主 | Rabbit | ||||||||
| 克隆类型 | Polyclonal | ||||||||
| 同种型 | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human ZFYVE27 (Lys361-Lys411). | ||||||||
| 靶标 | Spastic paraplegia 33 protein, SPG33, ZFYVE27, Protrudin, Zinc finger FYVE domain-containing protein 27 | ||||||||
| 纯化方式 | Purified by antigen affinity column. | ||||||||
| Accession号 | Q5T4F4 | ||||||||
| 状态 | Liquid | ||||||||
| 保存溶液 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
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| 产品使用信息 |
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| 稳定性和存储 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Protrudin (ZFYVE27) is a ~45 kDa protein. Key regulator of RAB11-dependent vesicular trafficking during neurite extension through polarized membrane transport. Promotes axonal elongation and contributes to the establishment of neuronal cell polarity. Involved in nerve growth factor-induced neurite formation in VAPA-dependent manner. Contributes to both the formation and stabilization of the tubular ER network. Involved in ER morphogenesis by regulating the sheet-to-tubule balance and possibly the density of tubule interconnections. 1. Shirane, M. et al. (2006) Science (New York, N.Y.) 314, 818-21. PMID: 17082457 2. Saita, S. et al. (2009) The Journal of biological chemistry 284, 13766-13777. PMID: 19289470 3. Hashimoto, Y. et al. (2014) The Journal of biological chemistry 289, 12946-61. PMID: 24668814 4. Chang, J. et al. (2013) Proceedings of the National Academy of Sciences of the United States of America 110, 14954-9. PMID: 23969831 5. Matsuzaki, F. et al. (2011) Molecular biology of the cell 22, 4602-20. PMID: 21976701 | ||||||||
| Note | For research use only. |

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