Anti-Human HEXIM1 Polyclonal Antibody (HF832014)

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规格：

50ug
100ug

数量：

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概述
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参考文献
产品说明书

HF832014

abinScience

种属反应性

Human, Mouse, Rat

ELISA, IHC, WB

Rabbit

Polyclonal

E. coli - derived recombinant Human HEXIM1 (Asp258-Asp359).

Protein HEXIM1, Cardiac lineage protein 1, HIS1, Menage a quatre protein 1, EDG1, Estrogen down-regulated gene 1 protein, HEXIM1, Hexamethylene bis-acetamide-inducible protein 1, MAQ1, CLP1

Purified by antigen affinity column.

Accession号

O94992

Liquid

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Protein HEXIM1 is a ~40 kDa protein. Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor. Core component of the 7SK RNP complex: in cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation. May also regulate NF-kappa-B, ESR1, NR3C1 and CIITA-dependent transcriptional activity. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway.

1. Yik, JH. et al. (2003) Molecular cell 12, 971-82. PMID: 14580347

2. Michels, AA. et al. (2004) The EMBO journal 23, 2608-19. PMID: 15201869

3. Yik, JH. et al. (2005) The Journal of biological chemistry 280, 16368-76. PMID: 15713661

4. Michels, AA. et al. (2003) Molecular and cellular biology 23, 4859-69. PMID: 12832472

5. Wittmann, BM. et al. (2005) Oncogene 24, 5576-88. PMID: 15940264

6. Shimizu, N. et al. (2005) Proceedings of the National Academy of Sciences of the United States of America 102, 8555-60. PMID: 15941832

7. Kohoutek, J. et al. (2006) Proceedings of the National Academy of Sciences of the United States of America 103, 17349-54. PMID: 17088550

8. Morchikh, M. et al. (2017) Molecular cell 67, 387-399.e5. PMID: 28712728

For research use only.

Western blot

Western blot analysis was performed using anti-HEXIM1 polyclonal antibody at 1ug/mL on various samples.
Lane 1: K562 cell lysate

产品说明书

Anti-Human HEXIM1 Polyclonal Antibody.pdf

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

分子量 *

g/mol

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

C₁ (起始浓度)

V₁ (起始体积)

C₂ (终浓度)

V₂ (终体积)

重组蛋白

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实验相关试剂

Anti-Human HEXIM1 Polyclonal Antibody (HF832014)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human HEXIM1 Polyclonal Antibody (HF832014)

概述

图片

参考文献

产品说明书

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