Anti-Human PRMT6 Polyclonal Antibody (HP638014)

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规格：

50ug
100ug

数量：

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概述
图片
参考文献
产品说明书

HP638014

abinScience

种属反应性

Human, Mouse

ELISA, IHC, WB

Rabbit

Polyclonal

E. coli - derived recombinant Human PRMT6 (Arg82-Asp375).

Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 6, Histone-arginine N-methyltransferase PRMT6, Protein arginine N-methyltransferase 6, PRMT6, HRMT1L6

Purified by antigen affinity column.

Accession号

Q96LA8

Liquid

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Protein arginine N-methyltransferase 6 (PRMT6) is a ~41 kDa protein. Arginine methyltransferase that can catalyze the formation of both omega-N monomethylarginine (MMA) and asymmetrical dimethylarginine (aDMA), with a strong preference for the formation of aDMA. Preferentially methylates arginyl residues present in a glycine and arginine-rich domain and displays preference for monomethylated substrates. Specifically mediates the asymmetric dimethylation of histone H3 'Arg-2' to form H3R2me2a. H3R2me2a represents a specific tag for epigenetic transcriptional repression and is mutually exclusive with methylation on histone H3 'Lys-4' (H3K4me2 and H3K4me3). Acts as a transcriptional repressor of various genes such as HOXA2, THBS1 and TP53.

1. Guccione, E. et al. (2007) Nature 449, 933-7. PMID: 17898714

2. Iberg, AN. et al. (2008) The Journal of biological chemistry 283, 3006-3010. PMID: 18077460

3. Hyllus, D. et al. (2007) Genes & development 21, 3369-80. PMID: 18079182

4. Lakowski, TM. et al. (2009) The Biochemical journal 421, 253-61. PMID: 19405910

5. Yan, WW. et al. (2018) EMBO reports 19. PMID: 30420520

For research use only.

产品说明书

Anti-Human PRMT6 Polyclonal Antibody.pdf

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

分子量 *

g/mol

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

C₁ (起始浓度)

V₁ (起始体积)

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human PRMT6 Polyclonal Antibody (HP638014)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human PRMT6 Polyclonal Antibody (HP638014)

概述

图片

参考文献

产品说明书

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