

| 货号 | HT060014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 品牌 | abinScience | ||||||||
| 种属反应性 | Human, Mouse, Rat | ||||||||
| 应用 | ELISA, IHC, WB | ||||||||
| 宿主 | Rabbit | ||||||||
| 克隆类型 | Polyclonal | ||||||||
| 同种型 | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human MGRN1 (Asp16-Gln251). | ||||||||
| 靶标 | KIAA0544, RING finger protein 156, RNF156, Mahogunin RING finger protein 1, E3 ubiquitin-protein ligase MGRN1, MGRN1, RING-type E3 ubiquitin transferase MGRN1 | ||||||||
| 纯化方式 | Purified by antigen affinity column. | ||||||||
| Accession号 | O60291 | ||||||||
| 状态 | Liquid | ||||||||
| 保存溶液 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
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| 产品使用信息 |
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| 稳定性和存储 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | E3 ubiquitin-protein ligase MGRN1 is a ~60 kDa protein. E3 ubiquitin-protein ligase. Mediates monoubiquitination at multiple sites of TSG101 in the presence of UBE2D1, but not of UBE2G1, nor UBE2H. Plays a role in the regulation of endosome-to-lysosome trafficking. Impairs MC1R- and MC4R-signaling by competing with GNAS-binding to MCRs and inhibiting agonist-induced cAMP production. Does not inhibit ADRB2-signaling. 1. Kim, BY. et al. (2007) Molecular biology of the cell 18, 1129-42. PMID: 17229889 2. Jiao, J. et al. (2009) Biochimica et biophysica acta 1792, 1027-35. PMID: 19703557 3. Pérez-Oliva, AB. et al. (2009) The Journal of biological chemistry 284, 31714-25. PMID: 19737927 | ||||||||
| Note | For research use only. |

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