Anti-Human RAB23 Polyclonal Antibody (HP968014)

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50ug
100ug

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概述
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参考文献
产品说明书

HP968014

abinScience

种属反应性

Human, Mouse

ELISA, IHC, WB

Rabbit

Polyclonal

E. coli - derived recombinant Human RAB23 (Met1-Ser186).

RAB23, Ras-related protein Rab-23

Purified by antigen affinity column.

Accession号

Q9ULC3

Liquid

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Ras-related protein Rab-23 (RAB23) is a ~26 kDa protein. The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. In conjunction with IFT57 and KIF17, it drives the localization of specific G protein-coupled receptors, such as the dopamime receptor DRD1, to primary cilia. Has a critical role in the formation and elongation of neuronal primary cilia, thereby impacting the activation of sonic hedgehog (Shh) signaling. Additionally, it is involved in the down-regulation of Shh signaling by cooperating with SUFU to prevent the nuclear import of GLI1 transcription factor, thus suppressing its transcriptional activity.

1. Leaf, A. et al. (2015) eLife 4. PMID: 26182404

2. Leong, WY. et al. (2025) PLoS genetics 21, e1011611. PMID: 40825043

3. Chi, S. et al. (2012) Cellular signalling 24, 1222-8. PMID: 22365972

4. Chau, YY. et al. (2025) The Journal of biological chemistry 301, 108036. PMID: 39615683

5. Nozawa, T. et al. (2012) Cellular microbiology 14, 1149-65. PMID: 22452336

For research use only.

产品说明书

Anti-Human RAB23 Polyclonal Antibody.pdf

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

分子量 *

g/mol

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

C₁ (起始浓度)

V₁ (起始体积)

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human RAB23 Polyclonal Antibody (HP968014)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human RAB23 Polyclonal Antibody (HP968014)

概述

图片

参考文献

产品说明书

相关产品推荐

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