Anti-Human NRDE2 Polyclonal Antibody (HP300014)

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50ug
100ug

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HP300014

abinScience

种属反应性

Human

ELISA, IHC, WB

Rabbit

Polyclonal

E. coli - derived recombinant Human NRDE2 (Thr162-Thr266).

Nuclear exosome regulator NRDE2, Protein NRDE2 homolog, C14orf102, NRDE2

Purified by antigen affinity column.

Accession号

Q9H7Z3

Liquid

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Nuclear exosome regulator NRDE2 is a ~132 kDa protein. Protein of the nuclear speckles that regulates RNA degradation and export from the nucleus through its interaction with MTREX an essential factor directing various RNAs to exosomal degradation. Changes the conformation of MTREX, precluding its association with the nuclear exosome and interaction with proteins required for its function in RNA exosomal degradation. Negatively regulates, for instance, the degradation of mRNAs and lncRNAs by inhibiting their MTREX-mediated recruitment to nuclear exosome. By preventing the degradation of RNAs in the nucleus, it promotes their export to the cytoplasm. U5 snRNP-associated RNA splicing factor which is required for efficient splicing of CEP131 pre-mRNA and plays an important role in centrosome maturation, integrity and function during mitosis.

1. Wang, J. et al. (2019) Genes & development 33, 536-549. PMID: 30842217

2. Jiao, AL. et al. (2019) RNA (New York, N.Y.) 25, 352-363. PMID: 30538148

3. Richard, P. et al. (2018) RNA biology 15, 868-876. PMID: 29902117

For research use only.

产品说明书

Anti-Human NRDE2 Polyclonal Antibody.pdf

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

分子量 *

g/mol

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

C₁ (起始浓度)

V₁ (起始体积)

C₂ (终浓度)

V₂ (终体积)

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Anti-Human NRDE2 Polyclonal Antibody (HP300014)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human NRDE2 Polyclonal Antibody (HP300014)

概述

图片

参考文献

产品说明书

相关产品推荐

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