

| 货号 | HT249014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 品牌 | abinScience | ||||||||
| 种属反应性 | Human, Mouse | ||||||||
| 应用 | ELISA, IHC, WB | ||||||||
| 宿主 | Rabbit | ||||||||
| 克隆类型 | Polyclonal | ||||||||
| 同种型 | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human CTNND1 (Glu367-Gln601). | ||||||||
| 靶标 | CTNND1, p120 catenin, Cadherin-associated Src substrate, CAS, Catenin delta-1, p120(ctn), KIAA0384, p120(cas) | ||||||||
| 纯化方式 | Purified by antigen affinity column. | ||||||||
| Accession号 | O60716 | ||||||||
| 状态 | Liquid | ||||||||
| 保存溶液 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
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| 产品使用信息 |
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| 稳定性和存储 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Catenin delta-1 (CTNND1) is a ~108 kDa protein. Key regulator of cell-cell adhesion that associates with and regulates the cell adhesion properties of both C-, E- and N-cadherins, being critical for their surface stability. Promotes localization and retention of DSG3 at cell-cell junctions, via its interaction with DSG3. Beside cell-cell adhesion, regulates gene transcription through several transcription factors including ZBTB33/Kaiso2 and GLIS2, and the activity of Rho family GTPases and downstream cytoskeletal dynamics. Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors. 1. Davis, MA. et al. (2003) The Journal of cell biology 163, 525-34. PMID: 14610055 2. Ishiyama, N. et al. (2010) Cell 141, 117-28. PMID: 20371349 3. Kanno, M. et al. (2008) Experimental cell research 314, 1683-92. PMID: 18343367 4. Daniel, JM. et al. (1999) Molecular and cellular biology 19, 3614-23. PMID: 10207085 5. Hosking, CR. et al. (2007) Molecular biology of the cell 18, 1918-27. PMID: 17344476 | ||||||||
| Note | For research use only. |

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