Anti-Human RBCK1 Polyclonal Antibody (HP909014)

价格:

规格：

50ug
100ug

数量：

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概述
图片
参考文献
产品说明书

HP909014

abinScience

种属反应性

Human

ELISA, IHC, WB

Rabbit

Polyclonal

E. coli - derived recombinant Human RBCK1 (Met1-Gly156).

RING finger protein 54, RNF54, RanBP-type and C3HC4-type zinc finger-containing protein 1, C20orf18, XAP4 X-associated protein 4, UBCE7IP3, RBCK1, RING-type E3 ubiquitin transferase HOIL-1, HOIL-1, Heme-oxidized IRP2 ubiquitin ligase 1, XAP3, Ubiquitin-conjugating enzyme 7-interacting protein 3, HBV-associated factor 4

Purified by antigen affinity column.

Accession号

Q9BYM8

Liquid

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

RanBP-type and C3HC4-type zinc finger-containing protein 1 (RBCK1) is a ~57 kDa protein. E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, such as UBE2L3/UBCM4, and then transfers it to substrates. Functions as an E3 ligase for oxidized IREB2 and both heme and oxygen are necessary for IREB2 ubiquitination. Promotes ubiquitination of TAB2 and IRF3 and their degradation by the proteasome. Component of the LUBAC complex which conjugates linear ('Met-1'-linked) polyubiquitin chains to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation. LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways.

1. Yamanaka, K. et al. (2003) Nature cell biology 5, 336-40. PMID: 12629548

2. Tian, Y. et al. (2007) The Journal of biological chemistry 282, 16776-82. PMID: 17449468

3. Zhang, M. et al. (2008) Cell research 18, 1096-104. PMID: 18711448

4. Kirisako, T. et al. (2006) The EMBO journal 25, 4877-87. PMID: 17006537

5. Tokunaga, F. et al. (2009) Nature cell biology 11, 123-32. PMID: 19136968

6. Gerlach, B. et al. (2011) Nature 471, 591-6. PMID: 21455173

7. Tokunaga, F. et al. (2011) Nature 471, 633-6. PMID: 21455180

8. Ikeda, F. et al. (2011) Nature 471, 637-41. PMID: 21455181

9. Noad, J. et al. (2017) Nature microbiology 2, 17063. PMID: 28481331

For research use only.

产品说明书

Anti-Human RBCK1 Polyclonal Antibody.pdf

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

分子量 *

g/mol

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

C₁ (起始浓度)

V₁ (起始体积)

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human RBCK1 Polyclonal Antibody (HP909014)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human RBCK1 Polyclonal Antibody (HP909014)

概述

图片

参考文献

产品说明书

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