

| 货号 | HX240014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 品牌 | abinScience | ||||||||
| 种属反应性 | Human, Mouse, Rat | ||||||||
| 应用 | ELISA, IHC, WB | ||||||||
| 宿主 | Rabbit | ||||||||
| 克隆类型 | Polyclonal | ||||||||
| 同种型 | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human SNU13 (Met1-Val128). | ||||||||
| 靶标 | High mobility group-like nuclear protein 2 homolog 1, SNU13, U4/U6.U5 tri-snRNP 15.5 kDa protein, OTK27, hSNU13, SNU13 homolog, U4/U6.U5 small nuclear ribonucleoprotein SNU13, NHP2-like protein 1, NHP2L1 | ||||||||
| 纯化方式 | Purified by antigen affinity column. | ||||||||
| Accession号 | P55769 | ||||||||
| 状态 | Liquid | ||||||||
| 保存溶液 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
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| 产品使用信息 |
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| 稳定性和存储 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | NHP2-like protein 1 (SNU13) is a ~14 kDa protein. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Involved in pre-mRNA splicing as component of the spliceosome. Binds to the 5'-stem-loop of U4 snRNA and thereby contributes to spliceosome assembly. The protein undergoes a conformational change upon RNA-binding. 1. Singh, S. et al. (2021) Science (New York, N.Y.) 373, eabj5338. PMID: 34516797 2. Bertram, K. et al. (2017) Cell 170, 701-713.e11. PMID: 28781166 3. Nottrott, S. et al. (1999) The EMBO journal 18, 6119-33. PMID: 10545122 4. Liu, S. et al. (2007) Science (New York, N.Y.) 316, 115-20. PMID: 17412961 5. Zhang, D. et al. (2024) Proceedings of the National Academy of Sciences of the United States of America 121, e2406961121. PMID: 39570315 | ||||||||
| Note | For research use only. |

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