Anti-Human MCM8 Polyclonal Antibody (HP407014)

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规格：

50ug
100ug

数量：

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概述
图片
参考文献
产品说明书

HP407014

abinScience

种属反应性

Human

ELISA, IHC, WB

Rabbit

Polyclonal

E. coli - derived recombinant Human MCM8 (Ser90-Lys366).

MCM8, C20orf154, Minichromosome maintenance 8, DNA helicase MCM8

Purified by antigen affinity column.

Accession号

Q9UJA3

Liquid

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

DNA helicase MCM8 is a ~93 kDa protein. Component of the MCM8-MCM9 complex, which is involved in the repair of double-stranded DNA breaks (DBSs) and DNA interstrand cross-links (ICLs) by homologous recombination (HR). The MCM8-MCM9 complex is a 3'-5' DNA helicase and single-stranded (ss)DNA-stimulated ATPase which binds ssDNA in the presence of nucleoside triphosphates. Required for DNA resection by the MRE11-RAD50-NBN/NBS1 (MRN) complex by recruiting the MRN complex to the repair site and by promoting the complex nuclease activity. Indirectly regulates the recruitment of downstream effector RAD51 to DNA damage sites including DBSs and ICLs, probably by regulating the localization of the MNR complex. The MCM8-MCM9 complex is dispensable for DNA replication and S phase progression.

1. Park, J. et al. (2013) Molecular and cellular biology 33, 1632-44. PMID: 23401855

2. McKinzey, DR. et al. (2023) Nucleic acids research 51, 7330-7341. PMID: 37309874

3. Lee, KY. et al. (2015) Nature communications 6, 7744. PMID: 26215093

4. Volkening, M. et al. (2005) Molecular and cellular biology 25, 1560-8. PMID: 15684404

5. Klucnika, A. et al. (2023) The Journal of cell biology 222. PMID: 36355348

For research use only.

产品说明书

Anti-Human MCM8 Polyclonal Antibody.pdf

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

分子量 *

g/mol

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

C₁ (起始浓度)

V₁ (起始体积)

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human MCM8 Polyclonal Antibody (HP407014)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human MCM8 Polyclonal Antibody (HP407014)

概述

图片

参考文献

产品说明书

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