Anti-Human PKD2 Polyclonal Antibody (HC405014)

价格:

规格：

50ug
100ug

数量：

一键复制产品信息

概述
图片
参考文献
产品说明书

HC405014

abinScience

种属反应性

Human

ELISA, IHC, WB

Rabbit

Polyclonal

E. coli - derived recombinant Human PKD2 (Met242-Thr468).

Autosomal dominant polycystic kidney disease type II protein, TRPP2, PC2, Polycystwin, Transient receptor potential cation channel subfamily P member 2, Polycystin-2, PKD2, Polycystic kidney disease 2 protein, R48321

Purified by antigen affinity column.

Accession号

Q13563

Liquid

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Polycystin-2 (PKD2) is a ~109 kDa protein. Forms a nonselective cation channel. Can function as a homotetrameric ion channel or can form heteromer with PKD1. Displays distinct function depending on its subcellular localization and regulation by its binding partners. In primary cilium functions as a cation channel, with a preference for monovalent cations over divalent cations that allows K(+), Na(+) and Ca(2+) influx, with low selectivity for Ca(2+). Involved in fluid-flow mechanosensation by the primary cilium in renal epithelium.

1. Koulen, P. et al. (2002) Nature cell biology 4, 191-7. PMID: 11854751

2. Gonzalez-Perrett, S. et al. (2002) The Journal of biological chemistry 277, 24959-66. PMID: 11991947

3. Köttgen, M. et al. (2005) The EMBO journal 24, 705-16. PMID: 15692563

4. Cantero, Mdel R. et al. (2015) The Journal of biological chemistry 290, 23888-96. PMID: 26269590

5. Arif Pavel, M. et al. (2016) Proceedings of the National Academy of Sciences of the United States of America 113, E2363-72. PMID: 27071085

6. Wang, Z. et al. (2019) EMBO reports 20, e48336. PMID: 31441214

7. Staudner, T. et al. (2024) The Journal of biological chemistry 300, 107574. PMID: 39009345

8. Ha, K. et al. (2020) eLife 9. PMID: 33164752

9. Kim, S. et al. (2016) Nature cell biology 18, 752-764. PMID: 27214281

For research use only.

产品说明书

Anti-Human PKD2 Polyclonal Antibody.pdf

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

分子量 *

g/mol

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

C₁ (起始浓度)

V₁ (起始体积)

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human PKD2 Polyclonal Antibody (HC405014)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human PKD2 Polyclonal Antibody (HC405014)

概述

图片

参考文献

产品说明书

相关产品推荐

获取报价