Anti-Human ZMYND8 Polyclonal Antibody (HP036014)

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规格：

50ug
100ug

数量：

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概述
图片
参考文献
产品说明书

HP036014

abinScience

种属反应性

Human

ELISA, IHC, WB

Rabbit

Polyclonal

E. coli - derived recombinant Human ZMYND8 (His111-Thr388).

Protein kinase C-binding protein 1, PRKCBP1, RACK7, ZMYND8, CTCL-associated antigen se14-3, Cutaneous T-cell lymphoma-associated antigen se14-3, Rack7, KIAA1125, Zinc finger MYND domain-containing protein 8

Purified by antigen affinity column.

Accession号

Q9ULU4

Liquid

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

MYND-type zinc finger-containing chromatin reader ZMYND8 is a ~131 kDa protein. Chromatin reader that recognizes dual histone modifications such as histone H3.1 dimethylated at 'Lys-36' and histone H4 acetylated at 'Lys-16' (H3.1K36me2-H4K16ac) and histone H3 methylated at 'Lys-4' and histone H4 acetylated at 'Lys-14' (H3K4me1-H3K14ac). May act as a transcriptional corepressor for KDM5D by recognizing the dual histone signature H3K4me1-H3K14ac. May also act as a transcriptional corepressor for KDM5C and EZH2. Recognizes acetylated histone H4 and recruits the NuRD chromatin remodeling complex to damaged chromatin for transcriptional repression and double-strand break repair by homologous recombination. Also activates transcription elongation by RNA polymerase II through recruiting the P-TEFb complex to target promoters.

1. Adhikary, S. et al. (2016) The Journal of biological chemistry 291, 2664-81. PMID: 26655721

2. Li, N. et al. (2016) Molecular cell 63, 470-84. PMID: 27477906

3. Mukherjee, S. et al. (2020) Journal of biosciences 45. PMID: 31965980

4. Adhikary, S. et al. (2022) Cell death & disease 13, 766. PMID: 36064715

5. Mukherjee, S. et al. (2020) Cell death & disease 11, 1073. PMID: 33323928

6. Gong, F. et al. (2015) Genes & development 29, 197-211. PMID: 25593309

7. Spruijt, CG. et al. (2016) Cell reports 17, 783-798. PMID: 27732854

8. Ghosh, K. et al. (2018) Cell reports 24, 2141-2154.e6. PMID: 30134174

For research use only.

产品说明书

Anti-Human ZMYND8 Polyclonal Antibody.pdf

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

分子量 *

g/mol

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

C₁ (起始浓度)

V₁ (起始体积)

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human ZMYND8 Polyclonal Antibody (HP036014)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human ZMYND8 Polyclonal Antibody (HP036014)

概述

图片

参考文献

产品说明书

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