Sentrin-specific protease 1 (SENP1) is a ~73 kDa protein. Protease that catalyzes two essential functions in the SUMO pathway. The first is the hydrolysis of an alpha-linked peptide bond at the C-terminal end of the small ubiquitin-like modifier (SUMO) propeptides, SUMO1, SUMO2 and SUMO3 leading to the mature form of the proteins. The second is the deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins, by cleaving an epsilon-linked peptide bond between the C-terminal glycine of the mature SUMO and the lysine epsilon-amino group of the target protein. Deconjugates SUMO1 from HIPK2. Deconjugates SUMO1 from HDAC1 and BHLHE40/DEC1, which decreases its transcriptional repression activity. 1. Gong, L. et al. (2000) The Journal of biological chemistry 275, 3355-9. PMID: 106523252. Cheng, J. et al. (2004) Molecular and cellular biology 24, 6021-8. PMID: 151991553. Xu, Z. et al. (2005) The Biochemical journal 386, 325-30. PMID: 154879835. Shen, LN. et al. (2006) The Biochemical journal 397, 279-88. PMID: 165535807. Cong, L. et al. (2011) The Journal of biological chemistry 286, 43793-43808. PMID: 219656789. Bi, H. et al. (2014) Molecular biology of the cell 25, 2499-508. PMID: 2494384410. Park, JH. et al. (2014) Nature communications 5, 5483. PMID: 25406032 | 
