

| 货号 | HY072014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 品牌 | abinScience | ||||||||
| 种属反应性 | Human | ||||||||
| 应用 | ELISA, IHC, WB | ||||||||
| 宿主 | Rabbit | ||||||||
| 克隆类型 | Polyclonal | ||||||||
| 同种型 | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human CNP (Glu40-Gly396). | ||||||||
| 靶标 | CNPase, 2', 3'-cyclic-nucleotide 3'-phosphodiesterase, CNP | ||||||||
| 纯化方式 | Purified by antigen affinity column. | ||||||||
| Accession号 | P09543 | ||||||||
| 状态 | Liquid | ||||||||
| 保存溶液 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
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| 产品使用信息 |
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| 稳定性和存储 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | 2',3'-cyclic-nucleotide 3'-phosphodiesterase (CNP) is a ~47 kDa protein. Myelin-associated enzyme that catalyzes the phosphodiester hydrolysis of 2',3'-cyclic nucleotides to 2'-nucleotides. In the mitochondria, regulates the functioning of the mitochondrial permeability transition pore (mPTP), and thus is involved in the mechanisms of cell death, both apoptosis and necrosis. Acts as an antiviral factor by suppressing the assembly of SARS-CoV-2 virions. 1. Logue, J. et al. (2023) PLoS pathogens 19, e1011870. PMID: 38117830 | ||||||||
| Note | For research use only. |

Western blot analysis was performed using anti-CNP polyclonal antibody at 1μg/ml on various samples.
Lane 1: HepG2 cell lysate
Lane 2: U251 cell lysate
Lane 3: Hela cell lysate
Lane 4: Mouse brain lysate
Lane 5: Mouse cerebellum lysate
Lane 6: Rat brain lysate
Lane 7: Rat cerebellum lysate



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