| 靶标 | Serine-protein kinase PIKFYVE, Phosphatidylinositol 3-phosphate 5-kinase, PIKfyve, 1-phosphatidylinositol 3-phosphate 5-kinase, PIKFYVE, FYVE finger-containing phosphoinositide kinase, Type III PIP kinase, PIPkin-III, KIAA0981, PIP5K3, Phosphatidylinositol 3-phosphate 5-kinase type III |
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| 背景 | 1-phosphatidylinositol 3-phosphate 5-kinase (PIKFYVE) is a ~237 kDa protein. Dual specificity kinase implicated in myriad essential cellular processes such as maintenance of endomembrane homeostasis, and endocytic-vacuolar pathway, lysosomal trafficking, nuclear transport, stress- or hormone-induced signaling and cell cycle progression. The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Sole enzyme to catalyze the phosphorylation of phosphatidylinositol 3-phosphate on the fifth hydroxyl of the myo-inositol ring, to form (PtdIns(3,5)P2). Also catalyzes the phosphorylation of phosphatidylinositol on the fifth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 5-phosphate (PtdIns(5)P). Has serine-protein kinase activity and is able to autophosphorylate and transphosphorylate. 1. Shisheva, A. (2012) Current topics in microbiology and immunology 362, 127-62. PMID: 230864172. Sbrissa, D. et al. (2007) The Journal of biological chemistry 282, 23878-91. PMID: 175563713. Sbrissa, D. et al. (2012) American journal of physiology. Cell physiology 303, C436-46. PMID: 226217864. Lees, JA. et al. (2020) Molecular cell 80, 736-743.e4. PMID: 330987646. Krishna, S. et al. (2016) Developmental cell 38, 536-47. PMID: 276233847. Dayam, RM. et al. (2017) Journal of immunology (Baltimore, Md. : 1950) 199, 2096-2105. PMID: 287790208. Liggins, MC. et al. (2018) PLoS genetics 14, e1007290. PMID: 29584722 |
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