

| 货号 | HT240014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 品牌 | abinScience | ||||||||
| 种属反应性 | Human, Mouse, Rat | ||||||||
| 应用 | ELISA, IHC, WB | ||||||||
| 宿主 | Rabbit | ||||||||
| 克隆类型 | Polyclonal | ||||||||
| 同种型 | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human ARPC1B (Met1-Lys372). | ||||||||
| 靶标 | Actin-related protein 2/3 complex subunit 1B, p41-ARC, Arp2/3 complex 41 kDa subunit, ARC41, ARPC1B | ||||||||
| 纯化方式 | Purified by antigen affinity column. | ||||||||
| Accession号 | O15143 | ||||||||
| 状态 | Liquid | ||||||||
| 保存溶液 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
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| 产品使用信息 |
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| 稳定性和存储 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Actin-related protein 2/3 complex subunit 1B (ARPC1B) is a ~40 kDa protein. Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs). 1. Gournier, H. et al. (2001) Molecular cell 8, 1041-52. PMID: 11741539 2. Welch, MD. et al. (1997) The Journal of cell biology 138, 375-84. PMID: 9230079 3. Schrank, BR. et al. (2018) Nature 559, 61-66. PMID: 29925947 | ||||||||
| Note | For research use only. |

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