| 背景 | LIM domain kinase 1 (LIMK1) is a ~72 kDa protein. Serine/threonine-protein kinase that plays an essential role in the regulation of actin filament dynamics. Acts downstream of several Rho family GTPase signal transduction pathways. Activated by upstream kinases including ROCK1, PAK1 and PAK4, which phosphorylate LIMK1 on a threonine residue located in its activation loop. LIMK1 subsequently phosphorylates and inactivates the actin binding/depolymerizing factors cofilin-1/CFL1, cofilin-2/CFL2 and destrin/DSTN, thereby preventing the cleavage of filamentous actin (F-actin), and stabilizing the actin cytoskeleton. In this way LIMK1 regulates several actin-dependent biological processes including cell motility, cell cycle progression, and differentiation. 1. Maekawa, M. et al. (1999) Science (New York, N.Y.) 285, 895-8. PMID: 104361593. Kaji, N. et al. (2003) The Journal of biological chemistry 278, 33450-5. PMID: 128079044. Soosairajah, J. et al. (2005) The EMBO journal 24, 473-86. PMID: 156601335. Nishita, M. et al. (2005) The Journal of cell biology 171, 349-59. PMID: 162304606. Acevedo, K. et al. (2007) Experimental cell research 313, 4091-106. PMID: 180289087. Heng, YW. et al. (2012) Journal of cell science 125, 1579-90. PMID: 223285148. Borroni, EM. et al. (2013) Science signaling 6, ra30.1-11, S1-3. PMID: 23633677 |
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