

| 货号 | HC340014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 品牌 | abinScience | ||||||||
| 种属反应性 | Human, Mouse | ||||||||
| 应用 | ELISA, IHC, WB | ||||||||
| 宿主 | Rabbit | ||||||||
| 克隆类型 | Polyclonal | ||||||||
| 同种型 | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human RBPJ (Arg30-Gly345). | ||||||||
| 靶标 | Recombining binding protein suppressor of hairless, RBP-J, IGKJRB, CBF-1, J kappa-recombination signal-binding protein, RBP-J kappa, RBP-JK, IGKJRB1, RBPJ, Renal carcinoma antigen NY-REN-30, RBPSUH, RBPJK | ||||||||
| 纯化方式 | Purified by antigen affinity column. | ||||||||
| Accession号 | Q06330 | ||||||||
| 状态 | Liquid | ||||||||
| 保存溶液 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
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| 产品使用信息 |
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| 稳定性和存储 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Recombining binding protein suppressor of hairless (RBPJ) is a ~55 kDa protein. Transcriptional regulator that plays a central role in Notch signaling, a signaling pathway involved in cell-cell communication that regulates a broad spectrum of cell-fate determinations. Acts as a transcriptional repressor when it is not associated with Notch proteins. When associated with some NICD product of Notch proteins (Notch intracellular domain), it acts as a transcriptional activator that activates transcription of Notch target genes. Probably represses or activates transcription via the recruitment of chromatin remodeling complexes containing histone deacetylase or histone acetylase proteins, respectively. Specifically binds to the immunoglobulin kappa-type J segment recombination signal sequence. 1. Bartels, SJ. et al. (2011) PloS one 6, e25884. PMID: 21991380 2. Aras, S. et al. (2013) Nucleic acids research 41, 2255-66. PMID: 23303788 | ||||||||
| Note | For research use only. |

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