Anti-Human HELLS Polyclonal Antibody (HV401014)

价格:

规格：

50ug
100ug

数量：

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概述
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参考文献
产品说明书

HV401014

abinScience

种属反应性

Human, Mouse

ELISA, IHC, WB

Rabbit

Polyclonal

E. coli - derived recombinant Human HELLS (Asp523-His748).

PASG, Lymphoid-specific helicase, SWI/SNF2-related matrix-associated actin-dependent regulator of chromatin subfamily A member 6, SMARCA6, HELLS, Proliferation-associated SNF2-like protein

Purified by antigen affinity column.

Accession号

Q9NRZ9

Liquid

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Lymphoid-specific helicase (HELLS) is a ~97 kDa protein. ATP-dependent chromatin remodeler that regulates chromatin accessibility, DNA methylation, and histone modifications. It facilitates de novo DNA methylation at repetitive sequences and promotes transcriptional silencing via recruitment of DNA methyltransferases (DNMTs) and histone deacetylases (HDACs), contributing to heterochromatin formation and repression of transposable elements. Also involved in DNA repair by recruiting DNA damage response mediators to double-strand breaks in heterochromatin, promoting homologous recombination via RBBP8/CtIP-dependent end resection. During meiosis, it is recruited by PRDM9 to recombination hotspots, aiding chromatin opening. Through these diverse roles, is crucial for processes such as development, differentiation, and genomic stability.

1. Unoki, M. et al. (2019) The Journal of clinical investigation 129, 78-92. PMID: 30307408

2. Burrage, J. et al. (2012) Journal of cell science 125, 5524-34. PMID: 22946062

3. Kollárovič, G. et al. (2020) Nucleic acids research 48, 1872-1885. PMID: 31802118

4. Spruce, C. et al. (2020) Genes & development 34, 398-412. PMID: 32001511

For research use only.

产品说明书

Anti-Human HELLS Polyclonal Antibody.pdf

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

分子量 *

g/mol

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

C₁ (起始浓度)

V₁ (起始体积)

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human HELLS Polyclonal Antibody (HV401014)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human HELLS Polyclonal Antibody (HV401014)

概述

图片

参考文献

产品说明书

相关产品推荐

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