Zinc finger protein 143 (ZNF143) is a ~68 kDa protein. Transcription factor that activates expression of genes transcribed by both RNA polymerases II and III, and which is required to safeguard mitochondrial activity. Specifically recognizes and binds the Staf-binding site (SBS), a consensus DNA-binding motif present in thousands of promoters. Activates the gene for selenocysteine tRNA (tRNAsec). Activates expression of small nuclear RNA (snRNA) transcribed by RNA polymerases II and III. Also activates expression of mRNAs and acts as a key regulator of cell proliferation and differentiation by specifically activating expression of a subset of nuclear-encoded mitochondrial genes, thereby controlling mitochondrial function. 1. Kubota, H. et al. (2000) The Journal of biological chemistry 275, 28641-8. PMID: 108932432. Grossman, CE. et al. (2004) The Journal of biological chemistry 279, 12190-205. PMID: 147023493. Yuan, CC. et al. (2007) Molecular and cellular biology 27, 8729-38. PMID: 179382084. Vinckevicius, A. et al. (2015) Molecular and cellular biology 35, 4135-46. PMID: 264168775. Narducci, DN. et al. (2025) Molecular cell 85, 9-23.e9. PMID: 397088036. Myslinski, E. et al. (1998) The Journal of biological chemistry 273, 21998-2006. PMID: 97053417. Rincon, JC. et al. (1998) Nucleic acids research 26, 4846-52. PMID: 97767438. Myslinski, E. et al. (2006) The Journal of biological chemistry 281, 39953-62. PMID: 170929459. Anno, YN. et al. (2011) Nucleic acids research 39, 3116-27. PMID: 2117765410. Ngondo-Mbongo, RP. et al. (2013) Nucleic acids research 41, 4000-14. PMID: 23408857 | 
