

| 货号 | HC692014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 品牌 | abinScience | ||||||||
| 种属反应性 | Human, Mouse, Rat | ||||||||
| 应用 | ELISA, IHC, WB | ||||||||
| 宿主 | Rabbit | ||||||||
| 克隆类型 | Polyclonal | ||||||||
| 同种型 | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human KHDRBS1 (Lys111-Gly276). | ||||||||
| 靶标 | p21 Ras GTPase-activating protein-associated p62, GAP-associated tyrosine phosphoprotein p62, KH domain-containing, RNA-binding, signal transduction-associated protein 1, SAM68, p68, Sam68, KHDRBS1, Src-associated in mitosis 68 kDa protein | ||||||||
| 纯化方式 | Purified by antigen affinity column. | ||||||||
| Accession号 | Q07666 | ||||||||
| 状态 | Liquid | ||||||||
| 保存溶液 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
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| 产品使用信息 |
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| 稳定性和存储 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | KH domain-containing, RNA-binding, signal transduction-associated protein 1 (KHDRBS1) is a ~48 kDa protein. Recruited and tyrosine phosphorylated by several receptor systems, for example the T-cell, leptin and insulin receptors. Once phosphorylated, functions as an adapter protein in signal transduction cascades by binding to SH2 and SH3 domain-containing proteins. Role in G2-M progression in the cell cycle. Represses CBP-dependent transcriptional activation apparently by competing with other nuclear factors for binding to CBP. Also acts as a putative regulator of mRNA stability and/or translation rates and mediates mRNA nuclear export. 1. Rajanala, K. et al. (2012) PloS one 7, e29921. PMID: 22253824 2. Nakka, KK. et al. (2015) Proceedings of the National Academy of Sciences of the United States of America 112, E3374-83. PMID: 26080397 3. Paronetto, MP. et al. (2007) The Journal of cell biology 176, 929-39. PMID: 17371836 4. Pedrotti, S. et al. (2010) The EMBO journal 29, 1235-47. PMID: 20186123 | ||||||||
| Note | For research use only. |

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