Anti-Human PRMT5 Polyclonal Antibody (HT245014)

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规格：

50ug
100ug

数量：

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概述
图片
参考文献
产品说明书

HT245014

abinScience

种属反应性

Human, Mouse

ELISA, IHC, WB

Rabbit

Polyclonal

E. coli - derived recombinant Human PRMT5 (Asn295-Gly466).

PRMT5, SKB1 homolog, 72 kDa ICln-binding protein, Jak-binding protein 1, Histone-arginine N-methyltransferase PRMT5, SKB1Hs, JBP1, Shk1 kinase-binding protein 1 homolog, SKB1, HRMT1L5, IBP72, Protein arginine N-methyltransferase 5

Purified by antigen affinity column.

Accession号

O14744

Liquid

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Protein arginine N-methyltransferase 5 (SKB1/PRMT5) is a ~72 kDa protein. Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles. Methylates SUPT5H and may regulate its transcriptional elongation properties. May methylate the N-terminal region of MBD2. Mono- and dimethylates arginine residues of myelin basic protein (MBP) in vitro.

1. Pollack, BP. et al. (1999) The Journal of biological chemistry 274, 31531-42. PMID: 10531356

2. Rho, J. et al. (2001) The Journal of biological chemistry 276, 11393-401. PMID: 11152681

3. Meister, G. et al. (2001) Current biology : CB 11, 1990-4. PMID: 11747828

4. Meister, G. et al. (2002) The EMBO journal 21, 5853-63. PMID: 12411503

5. Jiang, W. et al. (2005) Biochemical and biophysical research communications 329, 522-30. PMID: 15737618

6. Gonsalvez, GB. et al. (2007) The Journal of cell biology 178, 733-40. PMID: 17709427

7. Ren, J. et al. (2010) The Journal of biological chemistry 285, 12695-705. PMID: 20159986

8. Guo, S. et al. (2010) The Journal of biological chemistry 285, 35133-41. PMID: 20810653

9. Guderian, G. et al. (2011) The Journal of biological chemistry 286, 1976-86. PMID: 21081503

10. Hsu, JM. et al. (2011) Nature cell biology 13, 174-81. PMID: 21258366

For research use only.

产品说明书

Anti-Human PRMT5 Polyclonal Antibody.pdf

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

分子量 *

g/mol

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

C₁ (起始浓度)

V₁ (起始体积)

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

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实验相关试剂

Anti-Human PRMT5 Polyclonal Antibody (HT245014)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human PRMT5 Polyclonal Antibody (HT245014)

概述

图片

参考文献

产品说明书

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