Anti-Human EIF4A3/DDX48 Polyclonal Antibody (HW559014)

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规格：

50ug
100ug

数量：

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概述
图片
参考文献
产品说明书

HW559014

abinScience

种属反应性

Human, Mouse, Rat

ELISA, IHC, WB

Rabbit

Polyclonal

E. coli - derived recombinant Human EIF4A3/DDX48 (Phe40-Ile411).

ATP-dependent RNA helicase eIF4A-3, eIF-4A-III, Eukaryotic translation initiation factor 4A isoform 3, Eukaryotic initiation factor 4A-like NUK-34, Nuclear matrix protein 265, hNMP 265, KIAA0111, DDX48, NMP 265, eIF4A-III, Eukaryotic initiation factor 4A-III, ATP-dependent RNA helicase DDX48, EIF4A3, DEAD box protein 48

Purified by antigen affinity column.

Accession号

P38919

Liquid

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Eukaryotic initiation factor 4A-III (EIF4A3/DDX48) is a ~46 kDa protein. ATP-dependent RNA helicase. Involved in pre-mRNA splicing as component of the spliceosome. Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD).

1. Ballut, L. et al. (2005) Nature structural & molecular biology 12, 861-9. PMID: 16170325

2. Jurica, MS. et al. (2002) RNA (New York, N.Y.) 8, 426-39. PMID: 11991638

3. Barbosa, I. et al. (2012) Nature structural & molecular biology 19, 983-90. PMID: 22961380

4. Bertram, K. et al. (2017) Nature 542, 318-323. PMID: 28076346

5. Zhang, X. et al. (2017) Cell 169, 918-929.e14. PMID: 28502770

6. Zhan, X. et al. (2018) Science (New York, N.Y.) 359, 537-545. PMID: 29301961

7. Gehring, NH. et al. (2005) Molecular cell 20, 65-75. PMID: 16209946

8. Tange, TØ. et al. (2005) RNA (New York, N.Y.) 11, 1869-83. PMID: 16314458

9. Bono, F. et al. (2006) Cell 126, 713-25. PMID: 16923391

For research use only.

产品说明书

Anti-Human EIF4A3/DDX48 Polyclonal Antibody.pdf

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

分子量 *

g/mol

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

C₁ (起始浓度)

V₁ (起始体积)

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human EIF4A3/DDX48 Polyclonal Antibody (HW559014)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human EIF4A3/DDX48 Polyclonal Antibody (HW559014)

概述

图片

参考文献

产品说明书

相关产品推荐

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