Anti-HMGB1 Polyclonal Antibody (HY200014)

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规格：

50ug
100ug

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概述
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参考文献
产品说明书

HY200014

abinScience

种属反应性

Human, Mouse, Rat

ELISA, IHC, WB

Rabbit

Polyclonal

E. coli - derived recombinant Human HMGB1 (Met1-Glu215).

High mobility group protein B1, HMGB1, HMG1, HMG-1, High mobility group protein 1

Purified by antigen affinity column.

Accession号

P09429

Liquid

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

High mobility group protein B1 (HMGB1) is a ~24 kDa protein. Multifunctional redox sensitive protein with various roles in different cellular compartments. In the nucleus is one of the major chromatin-associated non-histone proteins and acts as a DNA chaperone involved in replication, transcription, chromatin remodeling, V(D)J recombination, DNA repair and genome stability. Proposed to be an universal biosensor for nucleic acids. Promotes host inflammatory response to sterile and infectious signals and is involved in the coordination and integration of innate and adaptive immune responses. In the cytoplasm functions as a sensor and/or chaperone for immunogenic nucleic acids implicating the activation of TLR9-mediated immune responses, and mediates autophagy.

1. Wei, J. et al. (2021) Cell 184, 76-91.e13. PMID: 33147444

2. Avgousti, DC. et al. (2016) Nature 535, 173-7. PMID: 27362237

3. Wang, G. et al. (2021) Cell death discovery 7, 337. PMID: 34743181

4. Yang, H. et al. (2013) Journal of leukocyte biology 93, 865-73. PMID: 23446148

5. Li, G. et al. (2013) Frontiers in immunology 4, 68. PMID: 23519706

6. Li, G. et al. (2013) Seminars in cancer biology 23, 380-90. PMID: 23994764

7. Lee, SA. et al. (2014) Yonsei medical journal 55, 1165-76. PMID: 25048472

8. Min, HJ. et al. (2013) Journal of immunology (Baltimore, Md. : 1950) 190, 1797-806. PMID: 23303669

9. Lee, LC. et al. (2014) PloS one 9, e115809. PMID: 25549101

For research use only.

产品说明书

Anti-HMGB1 Polyclonal Antibody.pdf

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

分子量 *

g/mol

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

C₁ (起始浓度)

V₁ (起始体积)

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-HMGB1 Polyclonal Antibody (HY200014)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-HMGB1 Polyclonal Antibody (HY200014)

概述

图片

参考文献

产品说明书

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