Transcription factor Sp1 is a ~80 kDa protein. Transcription factor that can activate or repress transcription in response to physiological and pathological stimuli. Binds with high affinity to GC-rich motifs and regulates the expression of a large number of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses. Highly regulated by post-translational modifications (phosphorylations, sumoylation, proteolytic cleavage, glycosylation and acetylation). Also binds the PDGFR-alpha G-box promoter. May have a role in modulating the cellular response to DNA damage. 1. Ding, H. et al. (1999) The Journal of biological chemistry 274, 19573-80. PMID: 103918912. Yang, X. et al. (2001) Proceedings of the National Academy of Sciences of the United States of America 98, 6611-6. PMID: 113716153. Milanini-Mongiat, J. et al. (2002) The Journal of biological chemistry 277, 20631-9. PMID: 119043054. Bonello, MR. et al. (2004) The Journal of biological chemistry 279, 2377-82. PMID: 145931155. Hsu, MC. et al. (2006) The Journal of biological chemistry 281, 4718-25. PMID: 163776296. Hung, JJ. et al. (2006) Molecular and cellular biology 26, 1770-85. PMID: 164789977. Zhang, Y. et al. (2006) Molecular and cellular biology 26, 6748-61. PMID: 169434188. Vicart, A. et al. (2006) Journal of molecular biology 364, 897-908. PMID: 170495559. Olofsson, BA. et al. (2007) Molecular cancer research : MCR 5, 1319-30. PMID: 1817199010. Chuang, JY. et al. (2008) Molecular biology of the cell 19, 1139-51. PMID: 18199680 | 
