Anti-ILK Polyclonal Antibody (HC502014)

价格:

规格：

50ug
100ug

数量：

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概述
图片
参考文献
产品说明书

HC502014

abinScience

种属反应性

Human, Mouse, Rat

ELISA, IHC, WB

Rabbit

Polyclonal

E. coli - derived recombinant Human ILK (Asn183-Lys452).

ILK, ILK2, ILK1, ILK-2, ILK-1, 59 kDa serine/threonine-protein kinase, Beta-integrin-linked kinase, p59ILK, Integrin-linked protein kinase

Purified by antigen affinity column.

Accession号

Q13418

Liquid

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Scaffold protein ILK is a ~51 kDa protein. Scaffold protein which mediates protein-protein interactions during a range of cellular events including focal adhesion assembly, cell adhesion and cell migration. Regulates integrin-mediated signal transduction by contributing to inside-out integrin activation. Recruits PARVA and LIMS1/PITCH to form the heterotrimeric IPP (ILK-PINCH-PARVIN) complex which binds to F-actin via the C-terminal tail of LIMS1 and the N-terminal region of PARVA, promoting F-actin filament bundling, a process required to generate force for actin cytoskeleton reorganization and subsequent dynamic cell adhesion events such as cell spreading and migration. Binding to PARVA promotes effective assembly of ILK into focal adhesions while PARVA-bound ILK can simultaneously engage integrin-beta cytoplasmic tails to mediate cell adhesion. Plays a role with PARVG in promoting the cell adhesion and spreading of leukocytes.

1. Acconcia, F. et al. (2007) Proceedings of the National Academy of Sciences of the United States of America 104, 6782-7. PMID: 17420447

2. Fukuda, K. et al. (2009) Molecular cell 36, 819-30. PMID: 20005845

3. Vaynberg, J. et al. (2018) Nature communications 9, 4465. PMID: 30367047

4. Yang, L. et al. (2020) Nature 583, 133-138. PMID: 32528174

5. Yoshimi, R. et al. (2006) Journal of immunology (Baltimore, Md. : 1950) 176, 3611-24. PMID: 16517730

6. Delcommenne, M. et al. (1998) Proceedings of the National Academy of Sciences of the United States of America 95, 11211-6. PMID: 9736715

7. Fielding, AB. et al. (2008) The Journal of cell biology 180, 681-9. PMID: 18283114

For research use only.

产品说明书

Anti-ILK Polyclonal Antibody.pdf

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

分子量 *

g/mol

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

C₁ (起始浓度)

V₁ (起始体积)

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-ILK Polyclonal Antibody (HC502014)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-ILK Polyclonal Antibody (HC502014)

概述

图片

参考文献

产品说明书

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