| 背景 | Tyrosine 3-monooxygenase (TH) is a ~58 kDa protein. Catalyzes the conversion of L-tyrosine to L-dihydroxyphenylalanine (L-Dopa), the rate-limiting step in the biosynthesis of catecholamines, dopamine, noradrenaline, and adrenaline. Uses tetrahydrobiopterin and molecular oxygen to convert tyrosine to L-Dopa (PubMed:15287903, PubMed:1680128, PubMed:17391063, PubMed:24753243, PubMed:34922205, PubMed:8528210, Ref.18). In addition to tyrosine, is able to catalyze the hydroxylation of phenylalanine and tryptophan with lower specificity. Positively regulates the regression of retinal hyaloid vessels during postnatal development. 1. Sura, GR. et al. (2004) Journal of neurochemistry 90, 970-8. PMID: 152879032. Le Bourdellès, B. et al. (1991) The Journal of biological chemistry 266, 17124-30. PMID: 16801283. Roma, J. et al. (2007) Biological chemistry 388, 419-26. PMID: 173910634. Fossbakk, A. et al. (2014) Human mutation 35, 880-90. PMID: 247532435. Inukai, S. et al. (2022) Biochemical and biophysical research communications 589, 209-214. PMID: 349222056. Knappskog, PM. et al. (1995) Human molecular genetics 4, 1209-12. PMID: 8528210 |
|---|
