Anti-Human CD169/SIGLEC1 Polyclonal Antibody (HV234014)

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100ug

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概述
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参考文献
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HV234014

abinScience

种属反应性

Human

ELISA, IHC, WB

Rabbit

Polyclonal

E. coli - derived recombinant Human CD169/SIGLEC1 (Gly34-Gly240).

Siglec-1, CD169, SIGLEC1, SN, Sialic acid-binding Ig-like lectin 1, Sialoadhesin

Purified by antigen affinity column.

Accession号

Q9BZZ2

Liquid

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Sialoadhesin (CD169/SIGLEC1) is a ~182 kDa protein. Macrophage-restricted adhesion molecule that mediates sialic-acid dependent binding to lymphocytes, including granulocytes, monocytes, natural killer cells, B-cells and CD8 T-cells. Plays a crucial role in limiting bacterial dissemination by engaging sialylated bacteria to promote effective phagocytosis and antigen presentation for the adaptive immune response. Mediates the uptake of various enveloped viruses via sialic acid recognition and subsequently induces the formation of intracellular compartments filled with virions (VCCs). In turn, enhances macrophage-to-T-cell transmission of several viruses including HIV-1 or SARS-CoV-2. Acts as an endocytic receptor mediating clathrin dependent endocytosis.

1. Jones, C. et al. (2003) Molecular microbiology 49, 1213-25. PMID: 12940982

2. Benet, S. et al. (2021) Journal of extracellular vesicles 10, e12046. PMID: 33489013

3. Hammonds, JE. et al. (2017) PLoS pathogens 13, e1006181. PMID: 28129379

4. Perez-Zsolt, D. et al. (2021) Cellular & molecular immunology 18, 2676-2678. PMID: 34782760

5. Zheng, Q. et al. (2015) Cell research 25, 1121-36. PMID: 26358190

For research use only.

产品说明书

Anti-Human CD169/SIGLEC1 Polyclonal Antibody.pdf

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

分子量 *

g/mol

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

C₁ (起始浓度)

V₁ (起始体积)

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human CD169/SIGLEC1 Polyclonal Antibody (HV234014)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human CD169/SIGLEC1 Polyclonal Antibody (HV234014)

概述

图片

参考文献

产品说明书

相关产品推荐

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