Anti-CYP27B1 Polyclonal Antibody (HT043014)

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规格：

50ug
100ug

数量：

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概述
图片
参考文献
产品说明书

HT043014

abinScience

种属反应性

Human

ELISA, IHC, WB

Rabbit

Polyclonal

E. coli - derived recombinant Human CYP27B1 (Asp256-Arg508).

25-hydroxyvitamin D(3) 1-alpha-hydroxylase, CYP27B, CYP27B1, Cytochrome P450C1 alpha, Calcidiol 1-monooxygenase, Cytochrome P450VD1-alpha, Cytochrome p450 27B1, CYP1ALPHA, Cytochrome P450 subfamily XXVIIB polypeptide 1, 25-OHD-1 alpha-hydroxylase, VD3 1A hydroxylase, 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial

Purified by antigen affinity column.

Accession号

O15528

Liquid

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial (CYP27B1) is a ~56 kDa protein. A cytochrome P450 monooxygenase involved in vitamin D metabolism and in calcium and phosphorus homeostasis. Catalyzes the rate-limiting step in the activation of vitamin D in the kidney, namely the hydroxylation of 25-hydroxyvitamin D3/calcidiol at the C1alpha-position to form the hormonally active form of vitamin D3, 1alpha,25-dihydroxyvitamin D3/calcitriol that acts via the vitamin D receptor (VDR). Has 1alpha-hydroxylase activity on vitamin D intermediates of the CYP24A1-mediated inactivation pathway. Converts 24R,25-dihydroxyvitamin D3/secalciferol to 1-alpha,24,25-trihydroxyvitamin D3, an active ligand of VDR. Also active on 25-hydroxyvitamin D2.

1. Sawada, N. et al. (1999) European journal of biochemistry 265, 950-6. PMID: 10518789

2. Kitanaka, S. et al. (1999) The Journal of clinical endocrinology and metabolism 84, 4111-7. PMID: 10566658

3. Wang, X. et al. (2002) The Journal of clinical endocrinology and metabolism 87, 2424-30. PMID: 12050193

4. Tang, EKY. et al. (2012) The FEBS journal 279, 3749-3761. PMID: 22862690

5. Kitanaka, S. et al. (1998) The New England journal of medicine 338, 653-61. PMID: 9486994

For research use only.

产品说明书

Anti-CYP27B1 Polyclonal Antibody.pdf

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

分子量 *

g/mol

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

C₁ (起始浓度)

V₁ (起始体积)

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

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实验相关试剂

Anti-CYP27B1 Polyclonal Antibody (HT043014)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-CYP27B1 Polyclonal Antibody (HT043014)

概述

图片

参考文献

产品说明书

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