| 靶标 | MAPKAPK2, MAPKAP-K2, MAPKAP kinase 2, MAPKAPK-2, MAP kinase-activated protein kinase 2, MK2, MK-2, MAPK-activated protein kinase 2 |
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| 背景 | MAP kinase-activated protein kinase 2 (MAPKAPK2) is a ~45 kDa protein. Stress-activated serine/threonine-protein kinase involved in cytokine production, endocytosis, reorganization of the cytoskeleton, cell migration, cell cycle control, chromatin remodeling, DNA damage response and transcriptional regulation. Following stress, it is phosphorylated and activated by MAP kinase p38-alpha/MAPK14, leading to phosphorylation of substrates. Phosphorylates serine in the peptide sequence, Hyd-X-R-X(2)-S, where Hyd is a large hydrophobic residue. Phosphorylates ALOX5, CDC25B, CDC25C, CEP131, ELAVL1, HNRNPA0, HSP27/HSPB1, KRT18, KRT20, LIMK1, LSP1, PABPC1, PARN, PDE4A, RCSD1, RPS6KA3, TAB3 and TTP/ZFP36. Phosphorylates HSF1; leading to the interaction with HSP90 proteins and inhibiting HSF1 homotrimerization, DNA-binding and transactivation activities. 1. Wang, X. et al. (2006) The Journal of biological chemistry 281, 782-91. PMID: 162782182. Tollenaere, MAX. et al. (2015) Nature communications 6, 10075. PMID: 26616734 |
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