Anti-CBR1 Polyclonal Antibody (HB037014)

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规格：

50ug
100ug

数量：

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概述
图片
参考文献
产品说明书

HB037014

abinScience

种属反应性

Human

ELISA, IHC, WB

Rabbit

Polyclonal

E. coli - derived recombinant Human CBR1 (Met1-Trp277).

CBR1, CRN, Prostaglandin 9-ketoreductase, Carbonyl reductase [NADPH] 1, Short chain dehydrogenase/reductase family 21C member 1, PG-9-KR, Prostaglandin-E(2) 9-reductase, 15-hydroxyprostaglandin dehydrogenase [NADP(+)], NADPH-dependent carbonyl reductase 1, CBR, 20-beta-hydroxysteroid dehydrogenase, SDR21C1

Purified by antigen affinity column.

Accession号

P16152

Liquid

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Carbonyl reductase [NADPH] 1 (CBR1) is a ~30 kDa protein. NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol. Can convert prostaglandin E to prostaglandin F2-alpha. Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates.

1. Tanaka, M. et al. (2005) PLoS biology 3, e128. PMID: 15799708

2. Gonzalez-Covarrubias, V. et al. (2007) Drug metabolism and disposition: the biological fate of chemicals 35, 973-80. PMID: 17344335

3. Bateman, R. et al. (2007) Organic & biomolecular chemistry 5, 3363-7. PMID: 17912391

4. Gonzalez-Covarrubias, V. et al. (2008) Pharmaceutical research 25, 1730-4. PMID: 18449627

5. Bateman, RL. et al. (2008) The Journal of biological chemistry 283, 35756-62. PMID: 18826943

6. Forrest, GL. et al. (1991) Molecular pharmacology 40, 502-7. PMID: 1921984

7. Wermuth, B. (1981) The Journal of biological chemistry 256, 1206-13. PMID: 7005231

8. Morgan, RA. et al. (2017) Scientific reports 7, 10633. PMID: 28878267

For research use only.

产品说明书

Anti-CBR1 Polyclonal Antibody.pdf

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

分子量 *

g/mol

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

C₁ (起始浓度)

V₁ (起始体积)

C₂ (终浓度)

V₂ (终体积)

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Anti-CBR1 Polyclonal Antibody (HB037014)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-CBR1 Polyclonal Antibody (HB037014)

概述

图片

参考文献

产品说明书

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