Anti-TNKS2 Polyclonal Antibody (HV525014)

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规格：

50ug
100ug

数量：

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概述
图片
参考文献
产品说明书

HV525014

abinScience

种属反应性

Human, Mouse

ELISA, IHC, WB

Rabbit

Polyclonal

E. coli - derived recombinant Human TNKS2 (Ser959-Gly1166).

TANK2, ADP-ribosyltransferase diphtheria toxin-like 6, Tankyrase-like protein, Poly [ADP-ribose] polymerase tankyrase-2, Tankyrase-related protein, TNKS2, Tankyrase II, ARTD6, Poly [ADP-ribose] polymerase 5B, Tankyrase-2, PARP5B, TNKL, TRF1-interacting ankyrin-related ADP-ribose polymerase 2, TNKS-2, Protein poly-ADP-ribosyltransferase tankyrase-2

Purified by antigen affinity column.

Accession号

Q9H2K2

Liquid

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Poly [ADP-ribose] polymerase tankyrase-2 (TNKS2) is a ~126 kDa protein. Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates poly-ADP-ribosylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates poly-ADP-ribosylation of TERF1, thereby contributing to the regulation of telomere length. Stimulates 26S proteasome activity.

1. Cook, BD. et al. (2002) Molecular and cellular biology 22, 332-42. PMID: 11739745

2. Sbodio, JI. et al. (2002) The Biochemical journal 361, 451-9. PMID: 11802774

3. Huang, SM. et al. (2009) Nature 461, 614-20. PMID: 19759537

4. Zhang, Y. et al. (2011) Nature cell biology 13, 623-9. PMID: 21478859

5. Cho-Park, PF. et al. (2013) Cell 153, 614-27. PMID: 23622245

6. Vyas, S. et al. (2014) Nature communications 5, 4426. PMID: 25043379

For research use only.

产品说明书

Anti-TNKS2 Polyclonal Antibody.pdf

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

分子量 *

g/mol

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

C₁ (起始浓度)

V₁ (起始体积)

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-TNKS2 Polyclonal Antibody (HV525014)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-TNKS2 Polyclonal Antibody (HV525014)

概述

图片

参考文献

产品说明书

相关产品推荐

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