Anti-NNMT Polyclonal Antibody (HW468014)

价格:

规格：

50ug
100ug

数量：

一键复制产品信息

概述
图片
参考文献
产品说明书

HW468014

abinScience

种属反应性

Human

ELISA, IHC, WB

Rabbit

Polyclonal

E. coli - derived recombinant Human NNMT (Met1-Arg258).

Nicotinamide N-methyltransferase, NNMT

Purified by antigen affinity column.

Accession号

P40261

Liquid

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Nicotinamide N-methyltransferase (NNMT) is a ~29 kDa protein. Catalyzes the N-methylation of nicotinamide using the universal methyl donor S-adenosyl-L-methionine to form N1-methylnicotinamide and S-adenosyl-L-homocysteine, a predominant nicotinamide/vitamin B3 clearance pathway. Plays a central role in regulating cellular methylation potential, by consuming S-adenosyl-L-methionine and limiting its availability for other methyltransferases. Actively mediates genome-wide epigenetic and transcriptional changes through hypomethylation of repressive chromatin marks, such as H3K27me3. In a developmental context, contributes to low levels of the repressive histone marks that characterize pluripotent embryonic stem cell pre-implantation state. Acts as a metabolic regulator primarily on white adipose tissue energy expenditure as well as hepatic gluconeogenesis and cholesterol biosynthesis.

1. Peng, Y. et al. (2011) Biochemistry 50, 7800-8. PMID: 21823666

2. Ulanovskaya, OA. et al. (2013) Nature chemical biology 9, 300-6. PMID: 23455543

3. Aksoy, S. et al. (1994) The Journal of biological chemistry 269, 14835-40. PMID: 8182091

4. Sperber, H. et al. (2015) Nature cell biology 17, 1523-35. PMID: 26571212

5. Eckert, MA. et al. (2019) Nature 569, 723-728. PMID: 31043742

6. Nemmara, VV. et al. (2018) ACS chemical biology 13, 2663-2672. PMID: 30044909

For research use only.

产品说明书

Anti-NNMT Polyclonal Antibody.pdf

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

分子量 *

g/mol

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

C₁ (起始浓度)

V₁ (起始体积)

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-NNMT Polyclonal Antibody (HW468014)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-NNMT Polyclonal Antibody (HW468014)

概述

图片

参考文献

产品说明书

相关产品推荐

获取报价