| 背景 | Cubilin (CUBN) is a ~398 kDa protein. Endocytic receptor which plays a role in lipoprotein, vitamin and iron metabolism by facilitating their uptake. Acts together with LRP2 to mediate endocytosis of high-density lipoproteins, GC, hemoglobin, ALB, TF and SCGB1A1. Acts together with AMN to mediate endocytosis of the CBLIF-cobalamin complex. Binds to ALB, MB, Kappa and lambda-light chains, TF, hemoglobin, GC, SCGB1A1, APOA1, high density lipoprotein, and the CBLIF-cobalamin complex. Ligand binding requires calcium. 1. Kozyraki, R. et al. (1999) Nature medicine 5, 656-61. PMID: 103715042. Kozyraki, R. et al. (2001) Proceedings of the National Academy of Sciences of the United States of America 98, 12491-6. PMID: 116067173. Nykjaer, A. et al. (2001) Proceedings of the National Academy of Sciences of the United States of America 98, 13895-900. PMID: 11717447 |
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