

| 货号 | HT196014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 品牌 | abinScience | ||||||||
| 种属反应性 | Human, Mouse | ||||||||
| 应用 | ELISA, IHC, WB | ||||||||
| 宿主 | Rabbit | ||||||||
| 克隆类型 | Polyclonal | ||||||||
| 同种型 | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human NARS1 (Met1-Arg330). | ||||||||
| 靶标 | Asparagine--tRNA ligase, cytoplasmic, NARS, NRS, Asparaginyl-tRNA synthetase, NARS1, Asparaginyl-tRNA synthetase 1, AsnRS | ||||||||
| 纯化方式 | Purified by antigen affinity column. | ||||||||
| Accession号 | O43776 | ||||||||
| 状态 | Liquid | ||||||||
| 保存溶液 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
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| 产品使用信息 |
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| 稳定性和存储 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Asparagine--tRNA ligase, cytoplasmic (NARS1) is a ~62 kDa protein. Catalyzes the attachment of asparagine to tRNA(Asn) in a two-step reaction: asparagine is first activated by ATP to form Asn-AMP and then transferred to the acceptor end of tRNA(Asn). In addition to its essential role in protein synthesis, acts as a signaling molecule that induced migration of CCR3-expressing cells. Has an essential role in the development of the cerebral cortex, being required for proper proliferation of radial glial cells. 1. Manole, A. et al. (2020) American journal of human genetics 107, 311-324. PMID: 32738225 2. Wang, L. et al. (2020) Nature communications 11, 4038. PMID: 32788587 3. Beaulande, M. et al. (1998) Nucleic acids research 26, 521-4. PMID: 9421509 4. Howard, OM. et al. (2002) The Journal of experimental medicine 196, 781-91. PMID: 12235211 5. Park, JS. et al. (2018) International journal of biological macromolecules 120, 835-845. PMID: 30171954 | ||||||||
| Note | For research use only. |

Lane 1: HepG2 cell lysate
Lane 2: K562 cell lysate
Lane 3: Hela cell lysate
Lane 4: RAW264.7 cell lysate
Lane 5: 293T cell lysate
Lane 6: LO2 cell lysate
Lane 7: Jurkat cell lysate



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