Anti-Human CTNS Polyclonal Antibody (HF632014)

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规格：

50ug
100ug

数量：

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概述
图片
参考文献
产品说明书

HF632014

abinScience

种属反应性

Human

ELISA, IHC, WB

Rabbit

Polyclonal

E. coli - derived recombinant Human CTNS (Ser22-Ser120).

CTNS, Cystinosin

Purified by antigen affinity column.

Accession号

O60931

Liquid

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Cystinosin (CTNS) is a ~41 kDa protein. Cystine/H(+) symporter that mediates export of cystine, the oxidized dimer of cysteine, from lysosomes. Plays an important role in melanin synthesis by catalyzing cystine export from melanosomes, possibly by inhibiting pheomelanin synthesis. In addition to cystine export, also acts as a positive regulator of mTORC1 signaling in kidney proximal tubular cells, via interactions with components of the v-ATPase and Ragulator complexes. Also involved in small GTPase-regulated vesicle trafficking and lysosomal localization of LAMP2A, independently of cystine transporter activity.

1. Kalatzis, V. et al. (2001) The EMBO journal 20, 5940-9. PMID: 11689434

2. Kalatzis, V. et al. (2004) Human molecular genetics 13, 1361-71. PMID: 15128704

3. Taranta, A. et al. (2008) American journal of physiology. Renal physiology 294, F1101-8. PMID: 18337546

4. Ruivo, R. et al. (2012) Proceedings of the National Academy of Sciences of the United States of America 109, E210-7. PMID: 22232659

5. Deshpande, AA. et al. (2018) Scientific reports 8, 3442. PMID: 29467429

6. Adelmann, CH. et al. (2020) Nature 588, 699-704. PMID: 33208952

7. Guo, X. et al. (2022) Cell 185, 3739-3752.e18. PMID: 36113465

8. Chiaverini, C. et al. (2012) FASEB journal : official publication of the Federation of American Societies for Experimental Biology 26, 3779-89. PMID: 22649030

For research use only.

产品说明书

Anti-Human CTNS Polyclonal Antibody.pdf

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

分子量 *

g/mol

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

C₁ (起始浓度)

V₁ (起始体积)

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human CTNS Polyclonal Antibody (HF632014)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human CTNS Polyclonal Antibody (HF632014)

概述

图片

参考文献

产品说明书

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