Anti-Human MBL2/MBP-C Polyclonal Antibody (HY274014)

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规格：

50ug
100ug

数量：

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概述
图片
参考文献
产品说明书

HY274014

abinScience

种属反应性

Human

ELISA, IHC, WB

Rabbit

Polyclonal

E. coli - derived recombinant Human MBL2/MBP-C (Gly131-Ile248).

COLEC1, Mannose-binding protein C, MBL2, Mannan-binding protein, MBP1, Mannose-binding lectin, MBL, Collectin-1, MBP-C

Purified by antigen affinity column.

Accession号

P11226

Liquid

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Mannose-binding protein C (MBL2/MBP-C) is a ~26 kDa protein. Calcium-dependent lectin, which acts as a pattern recognition receptor that initiates the lectin pathway of the complement system, a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system. Specifically recognizes and binds the mannose moiety of carbohydrates on the pathogen surface, activating the MASP1 serine protease and initiating the proteolytic cascade of the lectin complement pathway. Upon SARS coronavirus-2/SARS-CoV-2 infection, activates the complement lectin pathway which leads to the inhibition SARS-CoV-2 infection and a reduction of the induced inflammatory response. May bind DNA.

1. Nauta, AJ. et al. (2003) European journal of immunology 33, 2853-63. PMID: 14515269

2. Degn, SE. et al. (2012) Journal of immunology (Baltimore, Md. : 1950) 189, 3957-69. PMID: 22966085

3. Sheriff, S. et al. (1994) Nature structural biology 1, 789-94. PMID: 7634089

4. Thiel, S. et al. (1997) Nature 386, 506-10. PMID: 9087411

5. Super, M. et al. (1989) Lancet (London, England) 2, 1236-9. PMID: 2573758

6. Kawasaki, N. et al. (1983) Journal of biochemistry 94, 937-47. PMID: 6643429

7. van Emmerik, LC. et al. (1994) Clinical and experimental immunology 97, 411-6. PMID: 8082295

8. Stravalaci, M. et al. (2022) Nature immunology 23, 275-286. PMID: 35102342

For research use only.

产品说明书

Anti-Human MBL2/MBP-C Polyclonal Antibody.pdf

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

分子量 *

g/mol

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

C₁ (起始浓度)

V₁ (起始体积)

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human MBL2/MBP-C Polyclonal Antibody (HY274014)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human MBL2/MBP-C Polyclonal Antibody (HY274014)

概述

图片

参考文献

产品说明书

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