Anti-Human MCC Polyclonal Antibody (HB931014)

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100ug

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HB931014

abinScience

种属反应性

Human

ELISA, IHC, WB

Rabbit

Polyclonal

E. coli - derived recombinant Human MCC (Leu224-Ser294).

MCC, Protein MCC, Colorectal mutant cancer protein

Purified by antigen affinity column.

Accession号

P23508

Liquid

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Colorectal mutant cancer protein (MCC) is a ~93 kDa protein. Candidate for the putative colorectal tumor suppressor gene located at 5q21. Suppresses cell proliferation and the Wnt/b-catenin pathway in colorectal cancer cells. Inhibits DNA binding of b-catenin/TCF/LEF transcription factors. Involved in cell migration independently of RAC1, CDC42 and p21-activated kinase (PAK) activation. Represses the beta-catenin pathway (canonical Wnt signaling pathway) in a CCAR2-dependent manner by sequestering CCAR2 to the cytoplasm, thereby impairing its ability to inhibit SIRT1 which is involved in the deacetylation and negative regulation of beta-catenin (CTNB1) transcriptional activity.

1. Fukuyama, R. et al. (2008) Oncogene 27, 6044-55. PMID: 18591935

2. Arnaud, C. et al. (2009) FEBS letters 583, 2326-32. PMID: 19555689

3. Pangon, L. et al. (2012) Biochimica et biophysica acta 1823, 1058-67. PMID: 22480440

4. Pangon, L. et al. (2015) International journal of cancer 136, 55-64. PMID: 24824780

For research use only.

产品说明书

Anti-Human MCC Polyclonal Antibody.pdf

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

分子量 *

g/mol

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

C₁ (起始浓度)

V₁ (起始体积)

C₂ (终浓度)

V₂ (终体积)

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Anti-Human MCC Polyclonal Antibody (HB931014)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human MCC Polyclonal Antibody (HB931014)

概述

图片

参考文献

产品说明书

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