DnaJ homolog subfamily B member 2 (DNAJB2) is a ~35 kDa protein. Functions as a co-chaperone, regulating the substrate binding and activating the ATPase activity of chaperones of the HSP70/heat shock protein 70 family. In parallel, also contributes to the ubiquitin-dependent proteasomal degradation of misfolded proteins. Thereby, may regulate the aggregation and promote the functional recovery of misfolded proteins like HTT, MC4R, PRKN, RHO and SOD1 and be crucial for many biological processes. Isoform 1 which is localized to the endoplasmic reticulum membranes may specifically function in ER-associated protein degradation of misfolded proteins. 1. Gao, XC. et al. (2012) The Journal of biological chemistry 287, 6044-52. PMID: 222191992. Cheetham, ME. et al. (1994) European journal of biochemistry 226, 99-107. PMID: 79572633. Westhoff, B. et al. (2005) Current biology : CB 15, 1058-64. PMID: 159362785. Chapple, JP. et al. (2003) The Journal of biological chemistry 278, 19087-94. PMID: 127542726. Rose, JM. et al. (2011) Human molecular genetics 20, 16-27. PMID: 208894867. Meimaridou, E. et al. (2011) Molecular endocrinology (Baltimore, Md.) 25, 1650-60. PMID: 217195328. Labbadia, J. et al. (2012) Brain : a journal of neurology 135, 1180-96. PMID: 22396390 | 
