| 靶标 | Myristoylated alanine-rich C-kinase substrate, 80K-L protein, PKCSL, Protein kinase C substrate, 80 kDa protein, light chain, PRKCSL, MACS, MARCKS |
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| 背景 | Myristoylated alanine-rich C-kinase substrate (MARCKS) is a ~31 kDa protein. Membrane-associated protein that plays a role in the structural modulation of the actin cytoskeleton, chemotaxis, motility, cell adhesion, phagocytosis, and exocytosis through lipid sequestering and/or protein docking to membranes. Thus, exerts an influence on a plethora of physiological processes, such as embryonic development, tissue regeneration, neuronal plasticity, and inflammation. Sequesters phosphatidylinositol 4,5-bisphosphate (PIP2) at lipid rafts in the plasma membrane of quiescent cells, an action reversed by protein kinase C, ultimately inhibiting exocytosis. During inflammation, promotes the migration and adhesion of inflammatory cells and the secretion of cytokines such as tumor necrosis factor (TNF), particularly in macrophages. Plays an essential role in bacteria-induced intracellular reactive oxygen species (ROS) formation in the monocytic cell type. 1. Rodriguez Peña, MJ. et al. (2013) PloS one 8, e64551. PMID: 237049962. Huber, R. et al. (2022) Antioxidants (Basel, Switzerland) 11. PMID: 360093193. Issara-Amphorn, J. et al. (2023) Scientific reports 13, 19562. PMID: 37949888 |
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