| 靶标 | C/EBP-homologous protein, DDIT3, DDIT-3, CCAAT/enhancer-binding protein homologous protein, C/EBP zeta, CHOP-10, Growth arrest and DNA damage-inducible protein GADD153, DNA damage-inducible transcript 3 protein, GADD153, CHOP10, C/EBP-homologous protein 10, CHOP |
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| 背景 | DNA damage-inducible transcript 3 protein (CHOP/GADD153) is a ~19 kDa protein. Multifunctional transcription factor in endoplasmic reticulum (ER) stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer-binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression of C/EBP regulated genes. Positively regulates the transcription of TRIB3, IL6, IL8, IL23, TNFRSF10B/DR5, PPP1R15A/GADD34, BBC3/PUMA, BCL2L11/BIM and ERO1L. 1. Yamaguchi, H. et al. (2004) The Journal of biological chemistry 279, 45495-502. PMID: 153220752. Ohoka, N. et al. (2005) The EMBO journal 24, 1243-55. PMID: 157759884. Vij, N. et al. (2008) American journal of respiratory cell and molecular biology 38, 176-84. PMID: 177095995. Goodall, JC. et al. (2010) Proceedings of the National Academy of Sciences of the United States of America 107, 17698-703. PMID: 208761147. Su, N. et al. (2008) The Journal of biological chemistry 283, 35106-17. PMID: 189407928. Park, SH. et al. (2010) The Journal of biological chemistry 285, 35330-9. PMID: 20829347 |
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