

| 货号 | HW500014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 品牌 | abinScience | ||||||||
| 种属反应性 | Human, Mouse, Rat | ||||||||
| 应用 | ELISA, IHC, WB | ||||||||
| 宿主 | Rabbit | ||||||||
| 克隆类型 | Polyclonal | ||||||||
| 同种型 | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human HK2 (Trp619-Arg917). | ||||||||
| 靶标 | HK II, Hexokinase type II, Hexokinase-2, Hexokinase-B, HK2, Muscle form hexokinase | ||||||||
| 纯化方式 | Purified by antigen affinity column. | ||||||||
| Accession号 | P52789 | ||||||||
| 状态 | Liquid | ||||||||
| 保存溶液 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
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| 产品使用信息 |
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| 稳定性和存储 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Hexokinase-2 (HK2) is a ~102 kDa protein. Catalyzes the phosphorylation of hexose, such as D-glucose and D-fructose, to hexose 6-phosphate (D-glucose 6-phosphate and D-fructose 6-phosphate, respectively). Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate. Plays a key role in maintaining the integrity of the outer mitochondrial membrane by preventing the release of apoptogenic molecules from the intermembrane space and subsequent apoptosis. 1. Cheung, EC. et al. (2012) Proceedings of the National Academy of Sciences of the United States of America 109, 20491-6. PMID: 23185017 2. Lin, H. et al. (2016) ACS medicinal chemistry letters 7, 217-22. PMID: 26985301 3. Nawaz, MH. et al. (2018) Bioscience reports 38. PMID: 29298880 4. Chiara, F. et al. (2008) PloS one 3, e1852. PMID: 18350175 | ||||||||
| Note | For research use only. |

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