| 背景 | Defensin alpha 5 (DEFA5) is a ~10 kDa protein. Host-defense peptide that maintains sterility in the urogenital system. Has antimicrobial activity against a wide range of bacteria, including Gram-negative E.coli, P.aeruginosa and S.typhimurium, and Gram-positive E.aerogenes, S.aureus, B.cereus, E.faecium and L.monocytogenes. Confers resistance to intestinal infection by S.typhimurium. Exhibits antimicrobial activity against enteric commensal bacteria such as B.adolescentis, L.acidophilus, B.breve, L.fermentum, B.longum and S.thermophilus. Binds to bacterial membranes and causes membrane disintegration. 1. Ghosh, D. et al. (2002) Nature immunology 3, 583-90. PMID: 120217763. Ericksen, B. et al. (2005) Antimicrobial agents and chemotherapy 49, 269-75. PMID: 156163054. de Leeuw, E. et al. (2009) FEBS letters 583, 2507-12. PMID: 195893396. Rajabi, M. et al. (2012) The Journal of biological chemistry 287, 21615-27. PMID: 225733267. Schroeder, BO. et al. (2015) Mucosal immunology 8, 661-71. PMID: 253543188. Wang, C. et al. (2015) Journal of medicinal chemistry 58, 3083-93. PMID: 257821059. Ehmann, D. et al. (2019) Proceedings of the National Academy of Sciences of the United States of America 116, 3746-3751. PMID: 30808760 |
|---|
