Anti-Human SLC18A2 Polyclonal Antibody (HC560014)

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50ug
100ug

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概述
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参考文献
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HC560014

abinScience

种属反应性

Human

ELISA, IHC, WB

Rabbit

Polyclonal

E. coli - derived recombinant Human SLC18A2 (Pro42-Val129).

SVMT, VMAT2, Monoamine transporter, Synaptic vesicular amine transporter, VAT2, SLC18A2, Solute carrier family 18 member 2, Vesicular amine transporter 2

Purified by antigen affinity column.

Accession号

Q05940

Liquid

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Synaptic vesicular amine transporter (SLC18A2/VMAT2) is a ~55 kDa protein. Electrogenic antiporter that exchanges one cationic monoamine with two intravesicular protons across the membrane of secretory and synaptic vesicles. Uses the electrochemical proton gradient established by the V-type proton-pump ATPase to accumulate high concentrations of monoamines inside the vesicles prior to their release via exocytosis. Transports a variety of catecholamines such as dopamine, adrenaline and noradrenaline, histamine, and indolamines such as serotonin. Regulates the transvesicular monoaminergic gradient that determines the quantal size. Mediates somatodendritic dopamine release in hippocampal neurons, likely as part of a regulated secretory pathway that integrates retrograde synaptic signals.

1. Rilstone, JJ. et al. (2013) The New England journal of medicine 368, 543-50. PMID: 23363473

2. Pidathala, S. et al. (2023) Nature 623, 1086-1092. PMID: 37914936

3. Wu, D. et al. (2024) Nature 626, 427-434. PMID: 38081299

4. Dalton, MP. et al. (2024) eLife 12. PMID: 38517752

5. Erickson, JD. et al. (1996) Proceedings of the National Academy of Sciences of the United States of America 93, 5166-71. PMID: 8643547

6. Erickson, JD. et al. (1995) Journal of molecular neuroscience : MN 6, 277-87. PMID: 8860238

For research use only.

Western blot

Western blot analysis was performed using anti-SLC18A2 polyclonal antibody at 1ug/mL on various samples.
Lane 1: Jurkat cell lysate
Lane 2: K562 cell lysate

产品说明书

Anti-Human SLC18A2 Polyclonal Antibody.pdf

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

分子量 *

g/mol

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

C₁ (起始浓度)

V₁ (起始体积)

C₂ (终浓度)

V₂ (终体积)

重组蛋白

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试剂盒

实验相关试剂

Anti-Human SLC18A2 Polyclonal Antibody (HC560014)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human SLC18A2 Polyclonal Antibody (HC560014)

概述

图片

参考文献

产品说明书

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