

| 货号 | HC482014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 品牌 | abinScience | ||||||||
| 种属反应性 | Human | ||||||||
| 应用 | ELISA, IHC, WB | ||||||||
| 宿主 | Rabbit | ||||||||
| 克隆类型 | Polyclonal | ||||||||
| 同种型 | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human TCOF1 (Ala2-Arg77). | ||||||||
| 靶标 | TCOF1, Treacher Collins syndrome protein, Treacle protein | ||||||||
| 纯化方式 | Purified by antigen affinity column. | ||||||||
| Accession号 | Q13428 | ||||||||
| 状态 | Liquid | ||||||||
| 保存溶液 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
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| 产品使用信息 |
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| 稳定性和存储 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Treacle protein (TCOF1) is a ~152 kDa protein. Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification. Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with NOLC1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification. 1. Hayano, T. et al. (2003) The Journal of biological chemistry 278, 34309-19. PMID: 12777385 2. Werner, A. et al. (2015) Nature 525, 523-7. PMID: 26399832 | ||||||||
| Note | For research use only. |

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