Anti-FKBP5 Polyclonal Antibody (HC679014)

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规格：

50ug
100ug

数量：

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概述
图片
参考文献
产品说明书

HC679014

abinScience

种属反应性

Human, Rat

ELISA, IHC, WB

Rabbit

Polyclonal

E. coli - derived recombinant Human FKBP5 (Ser13-Lys252).

AIG6, 51 kDa FKBP, FKBP51, FKBP54, Rotamase, Peptidyl-prolyl cis-trans isomerase FKBP5, FF1 antigen, 51 kDa FK506-binding protein, FKBP-51, Androgen-regulated protein 6, p54, PPIase FKBP5, 54 kDa progesterone receptor-associated immunophilin, HSP90-binding immunophilin, FKBP-5, FK506-binding protein 5, FKBP5

Purified by antigen affinity column.

Accession号

Q13451

Liquid

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Peptidyl-prolyl cis-trans isomerase FKBP5 is a ~51 kDa protein. Immunophilin protein with PPIase and co-chaperone activities. Component of unligated steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). Plays a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors maintaining the complex into the cytoplasm when unliganded. Acts as a regulator of Akt/AKT1 activity by promoting the interaction between Akt/AKT1 and PHLPP1, thereby enhancing dephosphorylation and subsequent activation of Akt/AKT1. Interacts with IKBKE and IKBKB which facilitates IKK complex assembly leading to increased IKBKE and IKBKB kinase activity, NF-kappa-B activation, and IFN production.

1. Pirkl, F. et al. (2001) Journal of molecular biology 308, 795-806. PMID: 11350175

2. Sinars, CR. et al. (2003) Proceedings of the National Academy of Sciences of the United States of America 100, 868-73. PMID: 12538866

3. Yu, J. et al. (2017) Cell reports 18, 1229-1240. PMID: 28147277

4. Luo, K. et al. (2017) The EMBO journal 36, 1434-1446. PMID: 28363942

5. Romano, S. et al. (2015) Nucleic acids research 43, 6983-93. PMID: 26101251

6. DeDiego, ML. et al. (2019) Journal of virology 93. PMID: 31434731

For research use only.

产品说明书

Anti-FKBP5 Polyclonal Antibody.pdf

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

分子量 *

g/mol

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

C₁ (起始浓度)

V₁ (起始体积)

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-FKBP5 Polyclonal Antibody (HC679014)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-FKBP5 Polyclonal Antibody (HC679014)

概述

图片

参考文献

产品说明书

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