Anti-Human BRD3 Polyclonal Antibody (HS898014)

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50ug
100ug

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概述
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参考文献
产品说明书

HS898014

abinScience

种属反应性

Human, Mouse

ELISA, IHC, WB

Rabbit

Polyclonal

E. coli - derived recombinant Human BRD3 (Lys35-Gln139).

BRD3, RING3-like protein, Bromodomain-containing protein 3, KIAA0043, RING3L

Purified by antigen affinity column.

Accession号

Q15059

Liquid

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Bromodomain-containing protein 3 (BRD3) is a ~79 kDa protein. Chromatin reader that recognizes and binds acetylated histones, thereby controlling gene expression and remodeling chromatin structures. Recruits transcription factors and coactivators to target gene sites, and activates RNA polymerase II machinery for transcriptional elongation. In vitro, binds acetylated lysine residues on the N-terminus of histone H2A, H2B, H3 and H4. Involved in endoderm differentiation via its association with long non-coding RNA (lncRNA) DIGIT: BRD3 undergoes liquid-liquid phase separation upon binding to lncRNA DIGIT, promoting binding to histone H3 acetylated at 'Lys-18' (H3K18ac) to induce endoderm gene expression. Also binds non-histones acetylated proteins, such as GATA1 and GATA2: regulates transcription by promoting the binding of the transcription factor GATA1 to its targets.

1. LeRoy, G. et al. (2008) Molecular cell 30, 51-60. PMID: 18406326

2. Filippakopoulos, P. et al. (2012) Cell 149, 214-31. PMID: 22464331

3. Li, Y. et al. (2016) Molecular cell 62, 181-193. PMID: 27105114

4. Daneshvar, K. et al. (2020) Nature cell biology 22, 1211-1222. PMID: 32895492

5. Wai, DCC. et al. (2018) The Journal of biological chemistry 293, 7160-7175. PMID: 29567837

For research use only.

产品说明书

Anti-Human BRD3 Polyclonal Antibody.pdf

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

分子量 *

g/mol

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

C₁ (起始浓度)

V₁ (起始体积)

C₂ (终浓度)

V₂ (终体积)

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Anti-Human BRD3 Polyclonal Antibody (HS898014)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human BRD3 Polyclonal Antibody (HS898014)

概述

图片

参考文献

产品说明书

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