Anti-Human CPSF6 Polyclonal Antibody (HS787014)

价格:

规格：

50ug
100ug

数量：

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概述
图片
参考文献
产品说明书

HS787014

abinScience

种属反应性

Human, Mouse

ELISA, IHC, WB

Rabbit

Polyclonal

E. coli - derived recombinant Human CPSF6 (Lys79-Ser181).

Pre-mRNA cleavage factor Im 68 kDa subunit, CFIM68, Protein HPBRII-4/7, Cleavage and polyadenylation specificity factor subunit 6, CPSF6, CFIm68, CPSF 68 kDa subunit, Cleavage and polyadenylation specificity factor 68 kDa subunit, Cleavage factor Im complex 68 kDa subunit

Purified by antigen affinity column.

Accession号

Q16630

Liquid

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Cleavage and polyadenylation specificity factor subunit 6 (CPSF6) is a ~59 kDa protein. Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs. CPSF6 enhances NUDT21/CPSF5 binding to 5'-UGUA-3' elements localized upstream of pA signals and promotes RNA looping, and hence activates directly the mRNA 3'-processing machinery.

1. Brown, KM. et al. (2003) Molecular cell 12, 1467-76. PMID: 14690600

2. Zhu, Y. et al. (2018) Molecular cell 69, 62-74.e4. PMID: 29276085

3. Rüegsegger, U. et al. (1996) The Journal of biological chemistry 271, 6107-13. PMID: 8626397

4. Rüegsegger, U. et al. (1998) Molecular cell 1, 243-53. PMID: 9659921

5. Gruber, AR. et al. (2012) RNA biology 9, 1405-12. PMID: 23187700

6. Kim, S. et al. (2010) Genes to cells : devoted to molecular & cellular mechanisms 15, 1003-13. PMID: 20695905

For research use only.

产品说明书

Anti-Human CPSF6 Polyclonal Antibody.pdf

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

分子量 *

g/mol

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

C₁ (起始浓度)

V₁ (起始体积)

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human CPSF6 Polyclonal Antibody (HS787014)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human CPSF6 Polyclonal Antibody (HS787014)

概述

图片

参考文献

产品说明书

相关产品推荐

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