Anti-Human ZRANB3 Polyclonal Antibody (HV828014)

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规格：

50ug
100ug

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概述
图片
参考文献
产品说明书

HV828014

abinScience

种属反应性

Human

ELISA, IHC, WB

Rabbit

Polyclonal

E. coli - derived recombinant Human ZRANB3 (Asp27-Arg256).

Annealing helicase 2, ZRANB3, Zinc finger Ran-binding domain-containing protein 3, AH2, DNA annealing helicase and endonuclease ZRANB3

Purified by antigen affinity column.

Accession号

Q5FWF4

Liquid

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

DNA annealing helicase and endonuclease ZRANB3 is a ~123 kDa protein. DNA annealing helicase and endonuclease required to maintain genome stability at stalled or collapsed replication forks by facilitating fork restart and limiting inappropriate recombination that could occur during template switching events. Recruited to the sites of stalled DNA replication by polyubiquitinated PCNA and acts as a structure-specific endonuclease that cleaves the replication fork D-loop intermediate, generating an accessible 3'-OH group in the template of the leading strand, which is amenable to extension by DNA polymerase. In addition to endonuclease activity, also catalyzes the fork regression via annealing helicase activity in order to prevent disintegration of the replication fork and the formation of double-strand breaks.

1. Yusufzai, T. et al. (2010) Proceedings of the National Academy of Sciences of the United States of America 107, 20970-3. PMID: 21078962

2. Ciccia, A. et al. (2012) Molecular cell 47, 396-409. PMID: 22704558

3. Yuan, J. et al. (2012) Molecular cell 47, 410-21. PMID: 22705370

4. Weston, R. et al. (2012) Genes & development 26, 1558-72. PMID: 22759634

5. Badu-Nkansah, A. et al. (2016) The Journal of biological chemistry 291, 8251-7. PMID: 26884333

6. Sebesta, M. et al. (2017) Nature communications 8, 15847. PMID: 28621305

For research use only.

产品说明书

Anti-Human ZRANB3 Polyclonal Antibody.pdf

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

分子量 *

g/mol

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

C₁ (起始浓度)

V₁ (起始体积)

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human ZRANB3 Polyclonal Antibody (HV828014)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human ZRANB3 Polyclonal Antibody (HV828014)

概述

图片

参考文献

产品说明书

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