Anti-USP25 Polyclonal Antibody (HV501014)

价格:

规格：

50ug
100ug

数量：

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概述
图片
参考文献
产品说明书

HV501014

abinScience

种属反应性

Human, Mouse

ELISA, IHC, WB

Rabbit

Polyclonal

E. coli - derived recombinant Human USP25 (Glu862-Arg1055).

Ubiquitin-specific-processing protease 25, Ubiquitin thioesterase 25, USP21, USP on chromosome 21, Ubiquitin carboxyl-terminal hydrolase 25, Deubiquitinating enzyme 25, USP25

Purified by antigen affinity column.

Accession号

Q9UHP3

Liquid

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Ubiquitin carboxyl-terminal hydrolase 25 (USP25) is a ~122 kDa protein. Deubiquitinating enzyme that hydrolyzes ubiquitin moieties conjugated to substrates and thus, functions in various biological processes including inflammation and immune response. Modulates the Wnt/beta-catenin pathway by deubiquitinating and stabilizing tankyrases TNKS1 and TNKS2. Regulates KEAP1-NRF2 axis in the defense against oxidative assaults by deubiquitinating KEAP1 and protecting it from degradation leading to degradation of the NRF2 transcription factor that is responsible for mounting an anti-oxidation gene expression program. Positively regulates RNA virus-induced innate signaling by interacting with and deubiquitinating ERLIN1 and ERLIN2. In turn, restricts virus production by regulating cholesterol biosynthetic flux.

1. Qian, G. et al. (2018) Biochemical and biophysical research communications 498, 537-543. PMID: 29518389

2. Teo, QW. et al. (2023) Developmental cell 58, 2495-2509.e6. PMID: 37683630

3. Xu, D. et al. (2017) Genes & development 31, 1024-1035. PMID: 28619731

4. Sauer, F. et al. (2019) Molecular cell 74, 421-435.e10. PMID: 30926243

5. Fan, CX. et al. (2024) Brain : a journal of neurology 147, 3442-3457. PMID: 38875478

6. Cai, C. et al. (2023) Nature communications 14, 3648. PMID: 37339955

7. Zhong, B. et al. (2012) Nature immunology 13, 1110-7. PMID: 23042150

8. Wen, J. et al. (2019) Molecular immunology 106, 53-62. PMID: 30579117

For research use only.

产品说明书

Anti-USP25 Polyclonal Antibody.pdf

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

分子量 *

g/mol

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

C₁ (起始浓度)

V₁ (起始体积)

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-USP25 Polyclonal Antibody (HV501014)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-USP25 Polyclonal Antibody (HV501014)

概述

图片

参考文献

产品说明书

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